วันศุกร์ที่ 8 พฤษภาคม พ.ศ. 2569

Arthrocentesis & Intraarticular Glucocorticoid Injection

Arthrocentesis & Intraarticular Glucocorticoid Injection

Overview

Needle insertion into joint ทำเพื่อ:

1.       Arthrocentesis (diagnostic/therapeutic aspiration)

2.       Intraarticular injection

Most injections:

  • glucocorticoid
    ±
  • local anesthetic

INDICATIONS

1. Diagnostic Arthrocentesis

Most important indications

Suspected Septic Arthritis

ข้อสำคัญ:

septic arthritis ต้อง aspirate เสมอถ้าสงสัย

Especially important:

  • diabetic
  • immunocompromised
  • poor follow-up reliability

Important pearl

Septic arthritis:

coexist กับ gout/RA ได้

ดังนั้น:

  • culture
  • crystal analysis
    ควรทำพร้อมกัน

Timing

ควร aspirate:

BEFORE antibiotics

เพราะ antibiotics ทำให้:

  • synovial WBC ลดลง ~50%

2. Suspected Crystal Arthropathy

Gold standard diagnosis:

synovial crystal analysis

แม้:

  • US
  • DECT (dual-energy CT)
    ช่วยได้

แต่ aspiration ยัง preferred


Indications for Intraarticular Steroid Injection

Inflammatory arthritis

  • RA
  • PsA
  • spondyloarthritis
  • reactive arthritis

Crystal arthritis

  • gout
  • CPPD
  • BCP (Basic calcium phosphate crystal) arthritis

Osteoarthritis

Especially:

  • moderate-severe knee OA

RELATIVE CONTRAINDICATIONS

1. Septic arthritis

Absolute practical contraindication to steroid injection


2. Overlying cellulitis/periarticular infection

Risk:

  • inoculate infection into joint

3. Periarticular fracture

Steroid may impair bone healing


4. Planned arthroplasty

Important:

avoid steroid injection within 3 months before arthroplasty

Associated with:

  • PJI risk

5. Joint instability

Steroid may worsen:

  • ligament weakness
  • capsular laxity

6. Juxtaarticular osteoporosis


7. Repeated injections in OA

Repeated steroid injections:

  • diminishing benefit
  • possible cartilage toxicity

Important Point: Anticoagulation

Generally safe:

  • warfarin
  • DOACs
  • antiplatelet agents

Warfarin

Usually acceptable if:

  • INR 3–3.5

Unless:

  • septic joint suspected proceed urgently

INFORMED CONSENT

Discuss:

  • infection
  • postinjection flare
  • facial flushing
  • bleeding
  • leakage
  • steroid adverse effects

Important risks

Septic arthritis

Rare:
~1/1000–3000 procedures


Postinjection flare

~5%

Can mimic infection


Facial flushing

Up to 10%

Usually not allergy


EQUIPMENT

Needle size

Standard

22G ideal for most joints


Larger needle (18–20G)

Use for:

  • large knee effusion
  • viscous pus
  • Baker cyst
  • thick synovial fluid

Needle length

  • small/medium joints 1 inch
  • shoulder/knee 1.5–2 inch
  • obese patient longer

Syringe size

Preferred

5 mL often ideal


Large effusion

20–50 mL syringe


Important Pearl

Large syringe:

  • more resistance
  • harder to distinguish tendon injection

GENERAL PRINCIPLES OF NEEDLE ENTRY

Goals:

1.       easiest capsule access

2.       avoid neurovascular structures

3.       avoid skin lesions/infection

Needle:

bevel-up always


KNEE ARTHROCENTESIS (High-yield)

Preferred approaches

Suprapatellar approach

Best for:

  • large effusions

Parapatellar approach

Best for:

  • smaller effusions

Infrapatellar seated approach

Useful when:

  • wheelchair patient
  • cannot extend knee

Suboptimal for aspiration


Knee Position

Slight flexion:
15–20°


Key maneuver

Compression/manipulation:

increases aspiration success


HIP ASPIRATION

Usually:

image-guided only

Methods:

  • fluoroscopy
  • ultrasound

SHOULDER ASPIRATION

Anterior approach

Most commonly used


Posterior approach

Advantages:

  • less painful
  • patient doesn’t see needle

NO-TOUCH TECHNIQUE

Key principle:

avoid touching sterilized field

Sterile gloves not always necessary if proper no-touch technique used


Infection risk

Can reduce septic joint risk to:
<1/2000


SKIN PREPARATION

Preferred:

  • chlorhexidine
    or
  • iodine prep

Avoid:

alcohol alone


LOCAL ANESTHESIA

Lidocaine

  • 0.5–2 mL
  • along needle track

Disadvantage:

  • may reduce culture sensitivity

Ethyl chloride spray

Provides:
~15 sec anesthesia

Useful for:

  • quick skin puncture

JOINT ASPIRATION

Before steroid injection

Always visually inspect fluid


If fluid:

  • turbid
  • purulent
  • unexpectedly viscous

send:

  • Gram stain
  • culture
  • cell count

before steroid injection


Debulking Effusions

Benefits:

  • pain relief
  • chondrocyte damage
  • steroid effectiveness

Especially useful in:

  • RA knees
  • large tense effusions

Important Pearl

Aspiration before steroid injection:

lower relapse rate


SYNOVIAL FLUID STUDIES

Send when diagnosis uncertain:

  • cell count
  • differential
  • Gram stain
  • culture
  • crystal analysis

ULTRASOUND GUIDANCE

Indications

  • deep joints
  • obesity
  • difficult anatomy
  • failed aspiration (“dry tap”)
  • suspected septic joint

Particularly useful for

  • hip
  • shoulder
  • wrist
  • prosthetic joints

DRY TAP

Definition:

unable to aspirate fluid despite repositioning


Causes

1. Technical failure

Most common


2. Altered anatomy

  • prior surgery
  • deformity
  • trauma

3. Needle obstruction

  • synovium
  • plica
  • debris
  • viscous fluid

4. Small effusion


5. No actual effusion


Important Knee Dry Tap Causes

  • fat pad
  • plica
  • obesity

Approach to Dry Tap

1.       Change approach

2.       Compression maneuvers

3.       Ultrasound/fluoroscopy


Prosthetic Joint Pearl

Suspected septic prosthetic joint:

failed blind tap urgent fluoroscopic-guided aspiration

Orthopedic emergency


JOINT LAVAGE

Usually:

NOT recommended

because:

  • dilutes sample
  • complicates interpretation

Possible role:

  • prosthetic joint infection
  • sternoclavicular septic arthritis

POST-PROCEDURE CARE

Advise:

  • decrease weightbearing 24–48 hr
  • ice
  • OTC analgesics
  • keep site clean

FOLLOW-UP

Depends on disease:

  • OA injection months
  • inflammatory arthritis flare shorter follow-up

ANTICOAGULATION PEARLS

Generally safe:

  • warfarin
  • DOACs

Bleeding complications:

very rare


High-yield Clinical Pearls

  • Septic arthritis and gout can coexist
  • Aspirate before antibiotics whenever possible
  • Crystal analysis remains gold standard for gout diagnosis
  • Avoid steroid injection if septic arthritis suspected
  • Avoid steroid injection within 3 months before arthroplasty
  • Large viscous effusions may require 18–20G needle
  • Aspiration before steroid injection improves outcomes
  • Dry tap does not exclude septic arthritis
  • Ultrasound greatly improves success in difficult joints
  • Prosthetic joint infection + failed blind tap = fluoroscopic-guided aspiration urgently
  • Debulking tense effusions improves pain and may protect cartilage

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