Hematology

HEMATOLOGY

1. Fundamentals of Hematology

1.1 Hematopoiesis and stem cell biology
1.2 Structure and function of blood cells
1.3 Bone marrow microenvironment
1.4 Principles of hemostasis and coagulation
1.5 Overview of hematologic laboratory testing
1.6 Approach to anemia, leukocytosis, thrombocytopenia

2. Red Blood Cell Disorders

2.1 Anemia: General Approach

  • Classification (micro/normo/macro)
  • Reticulocyte-based algorithm
  • Iron metabolism & ferritin interpretation

2.2 Microcytic Anemias

  • Iron deficiency anemia
  • Anemia of chronic disease
  • Thalassemia (alpha, beta)
  • Sideroblastic anemia

2.3 Macrocytic Anemias

  • Vitamin B12 deficiency
  • Folate deficiency
  • Alcohol-related macrocytosis
  • Myelodysplastic syndromes (overview)

2.4 Hemolytic Anemia

  • Immune hemolysis (warm/cold AIHA)
  • Hereditary hemolytic anemias (HS, G6PD deficiency)
  • Microangiopathic hemolytic anemia (TTP, HUS, DIC)
  • Paroxysmal nocturnal hemoglobinuria (PNH)

3. White Blood Cell Disorders

3.1 Neutrophil Disorders

  • Neutropenia (congenital/acquired)
  • Neutrophilia
  • Functional disorders of neutrophils

3.2 Lymphocyte Disorders

  • Lymphocytosis (reactive vs clonal)
  • Lymphopenia
  • Primary immunodeficiency overview

3.3 Eosinophilia & Hypereosinophilic Syndromes

4. Platelet Disorders

4.1 Quantitative Platelet Disorders

  • Thrombocytopenia (ITP, drug-induced, inherited)
  • Thrombocytosis (reactive vs essential thrombocythemia)

4.2 Qualitative Platelet Disorders

  • Glanzmann thrombasthenia
  • Bernard–Soulier
  • Drug-induced platelet dysfunction (aspirin, NSAIDs)

5. Hemostasis and Coagulation Disorders

5.1 Bleeding Disorders

  • Hemophilia A/B
  • von Willebrand disease
  • Factor deficiencies
  • Liver disease-related coagulopathy

5.2 Hypercoagulability / Thrombophilia

  • Inherited (Factor V Leiden, prothrombin mutation)
  • Acquired (APS, malignancy, pregnancy, OCP)
  • Workup for unexplained thrombosis

6. Venous Thromboembolism (VTE)

6.1 Deep Vein Thrombosis (DVT)

6.2 Pulmonary Embolism (PE)

6.3 VTE Prophylaxis (Key Chapter)

6.4 Treatment of VTE

  • Anticoagulant selection
  • Indications for thrombolysis
  • Catheter-directed therapies

6.5 Long-term Management

  • Secondary prevention
  • Anticoagulation duration
  • Chronic thromboembolic pulmonary hypertension (CTEPH)

7. Malignant Hematology: Leukemias

7.1 Acute Leukemias

  • AML
  • ALL
  • APL (medical emergency)

7.2 Chronic Leukemias

  • CML
  • CLL

8. Lymphomas

8.1 Hodgkin Lymphoma

8.2 Non-Hodgkin Lymphoma

  • B-cell lymphomas
  • T-cell lymphomas
  • Indolent vs aggressive types

9. Plasma Cell Disorders

9.1 Multiple Myeloma

  • CRAB criteria
  • Diagnostic workup
  • Modern treatments (IMiDs, proteasome inhibitors, anti-CD38)

9.2 MGUS

9.3 Smoldering Myeloma

9.4 Amyloidosis (AL)

10. Bone Marrow Failure Syndromes

10.1 Aplastic anemia
10.2 PNH
10.3 Myelodysplastic syndromes (detailed)
10.4 Congenital marrow failure

11. Transfusion Medicine

11.1 Blood products
11.2 Compatibility testing
11.3 Massive transfusion protocol (MTP)
11.4 Transfusion reactions (acute & delayed)
11.5 Special situations (pediatrics, oncology, obstetrics)

12. Hematologic Emergencies

12.1 Febrile neutropenia
12.2 Tumor lysis syndrome
12.3 Hyperleukocytosis
12.4 DIC
12.5 TTP (ADAMTS13)
12.6 APL emergency
12.7 Severe bleeding (anticoagulant reversal agents)

13. Hematology in Special Populations

13.1 Pregnancy-associated hematologic issues
13.2 Hematology in CKD
13.3 Pediatric hematology overview
13.4 Hematologic issues in HIV
13.5 Hematology in critical care

14. Hematologic Pharmacology

14.1 Anticoagulants
14.2 Antiplatelets
14.3 Thrombolytics
14.4 Hemostatic agents (DDAVP, PCC, factor concentrates)
14.5 Iron therapy
14.6 Erythropoiesis-stimulating agents
14.7 Chemotherapy and targeted agents in hematologic malignancy

15. Procedures in Hematology

15.1 Bone marrow aspiration & biopsy
15.2 Peripheral smear interpretation
15.3 Leukapheresis
15.4 Plasma exchange (PLEX)
15.5 G-CSF mobilization for stem cell harvest

 

ไม่มีความคิดเห็น:

แสดงความคิดเห็น

สมัครสมาชิก: ความคิดเห็น (Atom)