HEMATOLOGY
1. Fundamentals of Hematology
- Hematopoiesis and stem cell biology
- Structure and function of blood cells
- Bone marrow microenvironment
- Principles of hemostasis and coagulation
- Overview of hematologic laboratory testing
- Peripheral blood smear
- Approach to Pancytopenia (Adult)
- Approach to Anemia (Adult)
- Approach to Anemia (Children)
- Approach to Erythrocytosis (Adult)
- Approach to Neutropenia (Adult)
- Approach to Neutropenia (Children)
- Approach to Neutrophilia (Adult)
- Approach to Lymphocytosis & Lymphocytopenia
- Approach to Eosinophilia (Adult)
- Approach to Thrombocytopenia
- Approach to Thrombocytosis (Adult)
- Approach to Suspected bleeding disorder
- Approach to Easy bruising
2. Red Blood Cell Disorders
2.1 Anemia: General Approach
- Approach to Anemia (Adult)
- Approach to Anemia (Children)
- Classification
(micro/normo/macro)
- Reticulocyte-based
algorithm
- Iron
metabolism & ferritin interpretation
2.2 Microcytic Anemias
- Microcytosis and Microcytic anemia
- Iron
deficiency anemia
- Anemia
of chronic disease
- Thalassemias
- Sideroblastic
anemia
2.3 Macrocytic Anemias
- Vitamin
B12 deficiency
- Folate
deficiency
- Alcohol-related
macrocytosis
- Myelodysplastic
syndromes (overview)
2.4 Hemolytic Anemia
- Immune
hemolysis (warm/cold AIHA)
- Hereditary
hemolytic anemias (HS, G6PD deficiency)
- Microangiopathic
hemolytic anemia (TTP, HUS, DIC)
- Paroxysmal
nocturnal hemoglobinuria (PNH)
- Sickle cell disease (overview)
3. White Blood Cell Disorders
3.1 Neutrophil Disorders
- Approach to Neutropenia (Adult)
- Approach to Neutropenia (Children)
- Approach to Neutrophilia (Adult)
- Lab Evaluation of Neutrophil Disorders
- Neutropenia
(congenital/acquired)
- Functional disorders of neutrophils
3.2 Lymphocyte Disorders
- Approach to Lymphocytosis & Lymphocytopenia
- Lymphocytosis
(reactive vs clonal)
- Lymphopenia
- Primary
immunodeficiency overview
3.3 Eosinophilia & Hypereosinophilic Syndromes
4. Platelet Disorders
4.1 Quantitative Platelet Disorders
- Approach to Thrombocytopenia
- Immune thrombocytopenia
- Thrombocytosis (reactive vs essential thrombocythemia)
4.2 Qualitative Platelet Disorders
- Glanzmann
thrombasthenia
- Bernard–Soulier
- Drug-induced
platelet dysfunction (aspirin, NSAIDs)
5. Hemostasis and Coagulation Disorders
5.1 Bleeding Disorders
- Approach to Suspected bleeding disorder
- Approach to Easy bruising
- Hemophilia
A/B
- von Willebrand disease
- Factor
deficiencies
- Liver
disease-related coagulopathy
- Bleeding disorder of unknown cause (BDUC)
5.2 Hypercoagulability / Thrombophilia
- Thrombophilia Testing
- Inherited
(Factor V Leiden, prothrombin mutation)
- Acquired
(APS, malignancy, pregnancy, OCP)
- Workup
for unexplained thrombosis
6. Venous Thromboembolism (VTE)
6.1 Deep Vein Thrombosis (DVT)
- Lower Extremity DVT
- Upper Extremity DVT
- Phlegmasia cerulea dorens/Phlegmasia alba dorens
- May-Thurner syndrome
6.2 Pulmonary Embolism (PE)
6.3 VTE Prophylaxis (Key Chapter)
- Risk stratification (Padua, Caprini)
- Medical
vs surgical patients
- Mechanical
prophylaxis
- Pharmacologic
prophylaxis
- UFH
- LMWH
- DOACs
- Fondaparinux
- Special
populations:
- Adult traveler
- Pregnancy
- Cancer
- Brain tumor
- Renal
failure
- Trauma/ICU
- Orthopedic surgery
- Nonorthopedic surgery
- Duration
& monitoring
6.4 Treatment of VTE
6.5 Long-term Management
- Secondary
prevention
- Anticoagulation
duration
- Chronic
thromboembolic pulmonary hypertension (CTEPH)
7. Malignant Hematology: Leukemias
see in Oncology
8. Lymphomas
see in Oncology
9. Plasma Cell Disorders
9.1 Multiple Myeloma
9.2 MGUS
9.3 Smoldering Myeloma
9.4 Amyloidosis (AL)
10. Bone Marrow Failure Syndromes
10.1 Aplastic anemia
10.2 PNH
10.3 Myelodysplastic syndromes (detailed)
10.4 Congenital marrow failure
11. Transfusion Medicine
11.1 Blood products
11.2 Compatibility testing
Massive transfusion protocol (MTP)
Transfusion reactions (acute & delayed)
Transfusion associated circulatory overload
11.5 Special situations (pediatrics, oncology, obstetrics)
12. Hematologic Emergencies
12.1 Febrile neutropenia
12.2 Tumor lysis syndrome
12.3 Hyperleukocytosis
12.4 DIC
12.5 TTP (ADAMTS13)
12.6 APL emergency
12.7 Severe bleeding (anticoagulant reversal agents)
Acute vaso-occlusive pain in Sickle cell disease
13. Hematology in Special Populations
13.1 Pregnancy-associated hematologic issues
13.2 Hematology in CKD
13.3 Pediatric hematology overview
13.4 Hematologic issues in HIV
13.5 Hematology in critical care
14. Hematologic Pharmacology
14.1 Anticoagulants
14.2 Antiplatelets
14.3 Thrombolytics
14.4 Hemostatic agents (DDAVP, PCC, factor concentrates)
14.5 Iron therapy
14.6 Erythropoiesis-stimulating agents
14.7 Chemotherapy and targeted agents in hematologic malignancy
15. Procedures in Hematology
15.1 Bone marrow aspiration & biopsy
15.2 Peripheral smear interpretation
15.3 Leukapheresis
15.4 Plasma exchange (PLEX)
15.5 G-CSF mobilization for stem cell harvest
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